Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines.
نویسندگان
چکیده
The enantioselective organocatalytic reduction of trifluoromethyl aryl and alkyl ketoimines afforded the corresponding fluorinated amines with high chemical and stereochemical efficiency. The Lewis base catalyzed reaction with trichlorosilane led to chiral products with a trifluoromethyl group directly linked to the newly generated stereocenter typically in >90% yield and up to 98% e.e.
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عنوان ژورنال:
- Chemical communications
دوره 49 75 شماره
صفحات -
تاریخ انتشار 2013